Opportunity Information: Apply for 72062423RFA00005

Systems to End the Malaria Burden Through Meaningful Engagement - II (SEMBE II) is a USAID-funded malaria program focused on Cameroon, designed to strengthen the ability of the Government of Cameroon and local partners to plan, manage, and deliver effective malaria prevention, control, and eventual elimination efforts. The activity is built around the idea that lasting malaria progress depends not only on commodities and technical interventions, but also on stronger national and sub-national systems, better coordination among stakeholders, and meaningful engagement of local institutions and communities so malaria services and decisions are increasingly led and sustained in-country.

SEMBE II is explicitly aligned with Cameroon’s National Strategic Plan (NSP) for Malaria Control for 2019 to 2023, and it is expected to adapt its emphasis as Cameroon updates future malaria strategic plans. The NSP priorities that frame SEMBE II’s intended results are clear and measurable: Cameroon aims to cut malaria morbidity and mortality by 60 percent compared with 2015 levels by 2023, reduce malaria incidence by 60 percent from 2015 levels by 2023, and push malaria transmission down to a very low level in selected health districts in the Sahelian zone, reaching a “pre-elimination threshold” by 2023. In practice, this means SEMBE II is meant to support a broad package of malaria programming across prevention, case management, surveillance, and health system strengthening, while also paying attention to geographic differences in transmission and the special requirements of lower-transmission districts working toward pre-elimination.

Funding for SEMBE II is expected to come primarily through the President’s Malaria Initiative (PMI), USAID’s flagship malaria funding stream. At the same time, the opportunity is designed with flexibility: USAID notes it can use “program modifiers” to adjust the activity if there are major shifts in USAID funding, changes in malaria epidemiology, or changes in the broader donor landscape in Cameroon. This is important because malaria programs can be disrupted by outbreaks, humanitarian pressures, climate-related shifts in transmission patterns, insecticide or drug resistance concerns, or changes in partner investments. SEMBE II is therefore positioned not only as a malaria activity, but as a platform that can be leveraged quickly to help respond to emerging health threats when needed, using existing systems, networks, and field presence.

From a grants and management standpoint, SEMBE II is a discretionary funding opportunity using a cooperative agreement, which typically means substantial involvement by USAID during implementation compared with a standard grant. The funding opportunity number is 72062423RFA00005, and the program is listed under CFDA/Assistance Listing 98.001. USAID Ghana (USAID-Accra) is the issuing agency listed in the notice, even though the implementation focus is Cameroon. The opportunity was posted May 8, 2023, with an original closing date of June 22, 2023. USAID anticipated making one award, with an award ceiling of up to $45,000,000, indicating a single, large implementer or consortium would be selected to deliver results at scale. Eligibility is listed as unrestricted (open to any type of entity), subject to any specific conditions that may appear in the full eligibility text of the solicitation.

Overall, SEMBE II can be understood as a large, multi-year systems-strengthening and service-delivery support effort aimed at helping Cameroon reach aggressive national malaria targets. It emphasizes national ownership and local stakeholder engagement, aligns implementation to the country’s strategic plan, and keeps room for program pivots if funding realities or health threats change.

  • The Agency for International Development, Ghana USAID-Accra in the health sector is offering a public funding opportunity titled "Systems to End the Malaria Burden Through Meaningful Engagement - II (SEMBE II)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001.
  • This funding opportunity was created on May 08, 2023.
  • Applicants must submit their applications by Jun 22, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $45,000,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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